There are two ways to do it. You can select the group from a popup window or you can activate group by looping the commands. Let's have an example: I have two button groups. I'll define a macro that has two commands, the first command activates the first button group and the second command activates the other button group. Then I check the option "One command, select". Now when I press the remote controller button a popup window will appear and the first command is selected as default. If I want to select the second command, I press a remote controller button again. If I wait awhile without pressing any button, the selected command will be executed. If I checked the option "One command, loop", I will be able to execute one command at a time. When I press the button for the first time, the first command is executed. When I press the button for the second time, the second command is executed. And next time the first command is executed etc.

Add two commands, first one for play and the second one for the pause and check the option "One command, loop". When you press the remote controller button for the first time, the play command is executed, next time the button is pressed the pause command is executed etc.

Just define a normal mouse click but set the action type as "button up".

You can define a macro (use current foreground window as the target window!) that sends mouse clicks to the start menu: click start button, click shut down, click suspend and finally ok. If the taskbar has the "Auto hide" feature enabled, it can be made visible by defining a mouse click (with "button up" action type) in the place where the task bar is placed (for example lower left corner of the screen). If the "Always on top" option of the task bar is disabled, the clicks on the start menu may not work.

When you set a macro to launch a file, check the option "Deactivate IRAssistant when application is launched". Now when IRAssistant launches the application, IRAssistant is deactivated automatically. When the application is closed, IRAssistant will be activated automatically. If the the application is already running and you want IRAssistant to activate itself when the application is closed, you must still use the "Launch file..." command but check the option "Allow only one instance running at a time". Now when the macro is executed, IRAssistant will not launch another instance of the application but now it'll know which application is "under control" and IRAssistant is activated when the application is closed.

Create one macro for the button group that launches the target application. Set this macro to be run when button group is activated (edit button group, select the macro from the list). Now every time you add a new macro to the group, the target application is specified automatically!

Create a shortcut of irassistant.exe to the startup menu. The path is usually the following: C:\Windows\Start Menu\Programs\StartUp.